Business Process Analysis and Implementation Strategies of Greening Logistics in Appliances Retail Industry

The whole world ecological environment worsens, and low-carbon economical and sustainable development becomes the general trend. The retail trade as the middle link of the whole economic cycle plays an important role on the relations of each essential factor in the entire economic environment. The concepts of low-carbon economy, and green logistics, and electrical appliances retail trade are discussed and the problems existing in the green logistics of the electrical appliances retail trade are explored. Based on the analysis of the business process and functions of green logistics in the electrical appliances retail trade, the system architecture of green logistics in the electrical appliances retail trade is established. Finally, the strategies and measures of greening logistics in the electrical appliances retail industry are proposed

Business Process Analysis and Implementation Strategies of Greening Logistics in Appliances Retail Industry

The whole world ecological environment worsens, and low-carbon economical and sustainable development becomes the general trend. The retail trade as the middle link of the whole economic cycle plays an important role on the relations of each essential factor in the entire economic environment. The concepts of low-carbon economy, and green logistics, and electrical appliances retail trade are discussed and the problems existing in the green logistics of the electrical appliances retail trade are explored. Based on the analysis of the business process and functions of green logistics in the electrical appliances retail trade, the system architecture of green logistics in the electrical appliances retail trade is established. Finally, the strategies and measures of greening logistics in the electrical appliances retail industry are proposed

Task-driven Semantic-aware Green Cooperative Transmission Strategy for Vehicular Networks

Considering the infrastructure deployment cost and energy consumption, it is unrealistic to provide seamless coverage of the vehicular network. The presence of uncovered areas tends to hinder the prevalence of the in-vehicle services with large data volume. To this end, we propose a predictive cooperative multi-relay transmission strategy (PreCMTS) for the intermittently connected vehicular networks, fulfilling the 6G vision of semantic and green communications. Specifically, we introduce a task-driven knowledge graph (KG)-assisted semantic communication system, and model the KG into a weighted directed graph from the viewpoint of transmission. Meanwhile, we identify three predictable parameters about the individual vehicles to perform the following anticipatory analysis. Firstly, to facilitate semantic extraction, we derive the closed-form expression of the achievable throughput within the delay requirement. Then, for the extracted semantic representation, we formulate the mutually coupled problems of semantic unit assignment and predictive relay selection as a combinatorial optimization problem, to jointly optimize the energy efficiency and semantic transmission reliability. To find a favorable solution within limited time, we proposed a low-complexity algorithm based on Markov approximation. The promising performance gains of the PreCMTS are demonstrated by the simulations with realistic vehicle traces generated by the SUMO traffic simulator.Comment: Accepted by IEEE Transactions on Communication

Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1

The leucine zipper, EF hand–containing transmembrane protein 1 (Letm1) gene encodes a mitochondrial inner membrane protein, whose depletion severely perturbs mitochondrial Ca2+ and K+ homeostasis. Here we expressed, purified, and reconstituted human Letm1 protein in liposomes. Using Ca2+ fluorophore and 45Ca2+-based assays, we demonstrate directly that Letm1 is a Ca2+ transporter, with apparent affinities of cations in the sequence of Ca2+ ≈ Mn2+ > Gd3+ ≈ La3+ > Sr2+ >> Ba2+, Mg2+, K+, Na+. Kinetic analysis yields a Letm1 turnover rate of 2 Ca2+/s and a Km of ∼25 µM. Further experiments show that Letm1 mediates electroneutral 1 Ca2+/2 H+ antiport. Letm1 is insensitive to ruthenium red, an inhibitor of the mitochondrial calcium uniporter, and CGP-37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger. Functional properties of Letm1 described here are remarkably similar to those of the H+-dependent Ca2+ transport mechanism identified in intact mitochondria

Effects of ovarian stimulation protocols on outcomes of assisted reproductive technology in adenomyosis women: a retrospective cohort study

ObjectiveTo evaluate the effects of different ovarian stimulation protocols on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in infertile women with adenomyosis.MethodsWe carried out a retrospective cohort study among infertile women with adenomyosis receiving IVF/ICSI treatment, including 257 fresh embryo transfer (ET) cycles and 305 frozen embryo transfer (FET) cycles. In fresh ET cycles, ultra-long, long, short, and antagonist protocols were adopted. In FET cycles, patients received long-acting GnRH agonist (GnRHa) pretreatment or not. The primary outcome was clinical pregnancy rate (CPR), and the secondary outcomes included implantation rate (IR), miscarriage rate (MR), and live birth rate (LBR).ResultsIn fresh ET cycles, compared with ultra-long and long protocols, IR (49.7%, 52.1% versus 28.2%, P=0.001) and CPR (64.3%, 57.4% versus 35.6%, P=0.004) significantly decreased in the short protocol. Similarly, compared with ultra-long and long protocols, a decreased inclination of IR (49.7%, 52.1% versus 33.3%) and CPR (57.4%, 64.3% versus 38.2%) existed in the antagonist protocol, although no statistical significance was detected because of strict P adjustment of Bonferroni method (Padj=0.008). Compared with long protocol, LBR in short protocol decreased obviously (48.2% versus 20.3%, P<0.001). In FET cycles, no matter which origin of embryos, there were no statistical differences in IR, CPR, and LBR. For women ≥35 years receiving fresh ET, CPR was higher in ultra-long and long protocols (52.1%, 50.0% versus 20.0%, 27.5%, P=0.031) compared to antagonist and short protocols. For women ≥35 years receiving FET, compared with ultra-long and antagonist protocols, cycles with embryos originating from long and short protocols had higher proportions of long-acting GnRHa pretreatment (30.4%,30.00 versus 63.9%, 51.4%, P=0.009). IR (61.1%, 48.6% versus 32.6%, 25.0%, P=0.020) and CPR (58.3%, 48.6% versus 30.4%, 25.0%, P=0.024) in long and short protocols were higher than rates of ultra-long and antagonist protocols, but no statistical differences were supported because of strict Bonferroni method (Padj=0.008).ConclusionIn infertile women with adenomyosis, if a fresh embryo was planned for transfer, an ultra-long or long protocol might be beneficial. If antagonist and short protocols were used, whole embryos frozen followed by FET was recommended. In FET cycles, embryos derived from different protocols had no impact on pregnancy outcomes

Effects of duration of long-acting GnRH agonist downregulation on assisted reproductive technology outcomes in patients with adenomyosis: a retrospective cohort study

ObjectivesTo elucidate the relationship between long-acting GnRH agonist (GnRHa) downregulation and assisted reproductive technology (ART) outcomes and identify the optimal duration of downregulation in patients with adenomyosis.DesignRetrospective cohort study.ParticipantsThe study was designed to evaluate ART outcomes in adenomyosis patients with and without GnRHa downregulation between January 2016 and December 2020. A total of 374 patients with adenomyosis (621 cycles) were included with 281 cycles in downregulation group versus 340 cycles in non-downregulation group. After 1:1 propensity score matching (PSM), a sample size of 272 cycles in each group was matched. The matched downregulation group was further divided into 1-month (147 cycles), 2-months (72 cycles), and ≥3 months downregulation (53 cycles) subgroups. Stratification analysis was conducted on pregnancy outcomes in 239 fresh embryo transfer (ET) cycles and 305 frozen embryo transfer (FET) cycles.ResultsThe downregulation group had larger mean diameter of initial uterus and higher proportion of severer dysmenorrhea compared to non-downregulation group. The pregnancy-related parameters in GnRHa downregulation group were similar to those in non-downregulation group, except for higher late miscarriage rate (MR) (13.4% vs. 3.1%, P = 0.003). The subgroup comparisons in fresh ET cycles indicated that implantation rate (75.0% vs. 39.2%, P = 0.002), biochemical pregnancy rate (91.7% vs. 56.0%, P = 0.036) and clinical pregnancy rate (83.3% vs. 47.0%, P = 0.016) could be improved by prolonged GnRHa downregulation (≥3 months), whereas late MR was difficult to be reversed (30.0% vs. 3.2%, P = 0.017). In FET cycles, higher MR (53.6% vs. 29.9%, P = 0.029; 58.8% vs. 29.9%, P = 0.026) and lower live birth rate (18.8% vs. 34.1%, P = 0.023; 17.1% vs. 34.1%, P = 0.037) were observed in the 1-month and ≥3 months downregulation group, while no differences were found in the 2-months downregulation group compared to the non-downregulation group.ConclusionIn patients with severer adenomyosis, long-acting GnRHa downregulation might be correlated with improved ART outcomes. In fresh ET cycles, prolonged downregulation (≥3 months) might be beneficial to improve live birth rate, which needed to be verified by further study with larger sample. In FET cycles, the optimal duration of downregulation was not certain and still needed further exploration

Study on Leading Vehicle Detection at Night Based on Multisensor and Image Enhancement Method

Low visibility is one of the reasons for rear accident at night. In this paper, we propose a method to detect the leading vehicle based on multisensor to decrease rear accidents at night. Then, we use image enhancement algorithm to improve the human vision. First, by millimeter wave radar to get the world coordinate of the preceding vehicles and establish the transformation of the relationship between the world coordinate and image pixels coordinate, we can convert the world coordinates of the radar target to image coordinate in order to form the region of interesting image. And then, by using the image processing method, we can reduce interference from the outside environment. Depending on D-S evidence theory, we can achieve a general value of reliability to test vehicles of interest. The experimental results show that the method can effectively eliminate the influence of illumination condition at night, accurately detect leading vehicles, and determine their location and accurate positioning. In order to improve nighttime driving, the driver shortage vision, reduce rear-end accident. Enhancing nighttime color image by three algorithms, a comparative study and evaluation by three algorithms are presented. The evaluation demonstrates that results after image enhancement satisfy the human visual habits

Adjusting the dose of traditional drugs combined with immunotherapy: reshaping the immune microenvironment in lung cancer

Immunotherapy is currently the most promising clinical treatment for lung cancer, not only revolutionizing second-line therapy but now also approved for first-line treatment. However, its clinical efficiency is not high and not all patients benefit from it. Thus, finding the best combination strategy to expand anti-PD-1/PD-L1-based immunotherapy is now a hot research topic. The conventional use of chemotherapeutic drugs and targeted drugs inevitably leads to resistance, toxic side effects and other problems. Recent research, however, suggests that by adjusting the dosage of drugs and blocking the activation of mutational mechanisms that depend on acquired resistance, it is possible to reduce toxic side effects, activate immune cells, and reshape the immune microenvironment of lung cancer. Here, we discuss the effects of different chemotherapeutic drugs and targeted drugs on the immune microenvironment. We explore the effects of adjusting the dosing sequence and timing, and the mechanisms of such responses, and show how the effectiveness and reliability of combined immunotherapy provide improved treatment outcomes

Who can help me? Understanding the antecedent and consequence of medical information seeking behavior in the era of bigdata

IntroductionThe advent of bigdata era fundamentally transformed the nature of medical information seeking and the traditional binary medical relationship. Weaving stress coping theory and information processing theory, we developed an integrative perspective on information seeking behavior and explored the antecedent and consequence of such behavior.MethodsData were collected from 573 women suffering from infertility who was seeking assisted reproductive technology treatment in China. We used AMOS 22.0 and the PROCESS macro in SPSS 25.0 software to test our model.ResultsOur findings demonstrated that patients’ satisfaction with information received from the physicians negatively predicted their behavior involvement in information seeking, such behavior positively related to their perceived information overload, and the latter negatively related to patient-physician relationship quality. Further findings showed that medical information seeking behavior and perceived information overload would serially mediate the impacts of satisfaction with information received from physicians on patient-physician relationship quality.DiscussionThis study extends knowledge of information seeking behavior by proposing an integrative model and expands the application of stress coping theory and information processing theory. Additionally, it provides valuable implications for patients, physicians and public health information service providers